Ototoxic Drugs - Archive

Cisplatin may cause more permanent hearing loss in people with Cockayne syndrome

May 24, 2016 in Community News, Research

 

 

Science Daily
May 19, 2016

Chemotherapy drug cisplatin is used to treat breast, prostate, neuroblastoma, melanoma and many other cancers

Date:
May 18, 2016
Source:
University of Southern California
Summary:
The chemotherapy drug cisplatin can kill cancer, but it can also cause permanent hearing loss. The drug can kill the sensory cells of the inner ear, a phenomenon that is likely more severe in individuals with Cockayne syndrome, a rare form of dwarfism. The disorder results from mutations in one of two genes involved in repairing DNA damage. Cells can sustain DNA damage from environmental stresses ranging from the sun’s ultraviolet radiation to toxic chemicals such as chemotherapy drugs.
Read full Article . . . cisplatin 
Other Source: Key mutations may worsen hearing loss from the chemotherapy drug cisplatin

Beware of (Ototoxic) Drugs That Can Damage Your Ears

January 14, 2016 in Hearing Loss & Deafness

 

By HEARING LOSS HELP e-Zine
 “The premier e-Zine for people with hearing loss”

The Ototoxicity of Drugs Ending in“-mycin” (and “–micin”)
by Neil Bauman, Ph.D.

A number of people believe that drugs ending in “–mycin” (and
“-micin”) are all members of the extremely ototoxic Aminoglycoside
class of antibiotic drugs and should be avoided so they don’t damage
their ears. This is not totally true.

It is true that about half of the generic drugs ending in “–mycin” and
“–micin” are indeed members of the Aminoglycoside class of drugs.
However, it is just as true that about half of the drugs ending in
“–mycin” and “–micin” are not Aminoglycosides. Furthermore, some
Aminoglycoside drugs do not end in “–mycin” or “–micin”.

Complicating things further, not only do a number of generic drug
names end in –mycin and –micin, but so do a number of brand
names—again about half of which are Aminoglycoside drugs, and half are
not.

Therefore, when you come across a drug name ending in “–mycin” or
“–micin” don’t automatically assume it is an Aminoglycoside drug.
(You’d be wrong about 50% of the time if you do.)

Below is a list of all the drugs (generic and brand names) that end in
“–mycin” or “–micin” of which I’m aware. All of them are ototoxic to
some degree—ranging from mildly ototoxic to extremely ototoxic.
Generic names ending in “-mycin/-micin” are in bold. Brand names are
in bold italics and drug class names are in UPPER CASE.

See List of all drugs . . . HEARING LOSS HELP e-Zine

_______________

If you want to learn more about the ototoxic side effects of the
-mycins (or any other drugs), see the details of my book “Ototoxic
Drugs Exposed” 3rd edition or order one for yourself at
http://hearinglosshelp.com/shop/ototoxic-drugs-exposed/ . This book
contains information on the ototoxicity of 877 drugs, 35 herbs and 148
chemicals.
_______________

The permanent link for this article is on the Center’s website at
http://hearinglosshelp.com/blog/the-ototoxicity-of-drugs-ending-in-
mycin-and-micin/
 (or http://hearinglosshelp.com/?p=4714 if the
preceding link is broken).

Silent Side Effect: Could Your Medication Cause Hearing Loss?

November 3, 2015 in Community News, Research

 

Certain OTC pain relievers, prescription antibiotics and other drugs may damage hearing.

US News – Health
By Michael O. Schroeder

Drug labels routinely describe myriad potential side effects stemming from taking a given medication.

Yet, one newly recognized risk usually goes unmentioned: hearing loss. “There are a number of common medications that are ototoxic, which means harmful to the ears,” says Dr. Sharon Curhan, a physician and epidemiologist at the Channing Division of Network Medicine at Brigham and Women’s Hospital and Harvard Medical School in Boston. That side effect isn’t typically listed on drug labels, she says. “These are relatively new findings.”

Research by Curhan and others finds that some over-the-counter medications, acetaminophen (the generic name for Tylenol), ibuprofen and prescriptions, ranging from certain antibiotics to chemotherapy drugs, can damage hearing. In all, there are more than 200 known ototoxic medications on the market today, according to the American-Speech-Language-Hearing Association, which can also impact the ear’s balance functions.

Read More . . . Drugs

 

Deaf or Death? In Drug Trial, Parents Weigh Life vs. Hearing Loss

March 10, 2015 in Hearing Loss & Deafness, Research

 

 

An experimental treatment could let children with a rare genetic disease live longer, but it may make them deaf

BETHESDA, Md.—While waiting for an infusion of a drug that might save his life, 15-year-old Andrew Marella gripped the controls of an NFL videogame, the hand-held version of a sport he played when he could still run without fear.

Andrew is in a clinical drug trial of cyclodextrin, a sugar-based substance that scientists hope will stop or slow the progress of a rare genetic disease that kills most patients by the time they are old enough to vote.

There is a good chance cyclodextrin will extend Andrew’s life. But his parents worry this will be the dose that leaves him deaf.

Families in the drug trial must decide whether to permit the higher doses of cyclodextrin that research shows might arrest the disease. Hearing loss is one side effect. “Deaf or death, what are our options?” said Andrea Marella, Andrew’s mother. “We have to keep moving forward.”

Read more  . . . Deaf or Death?