myosin 15 gene (MYO15A) - Archive

NIDCD Scientists Advance Understanding of Molecules in Deafness Genes, Head & Neck Cancers

August 14, 2014 in Research

 

 

NIH-NID

August 12, 2014

NIDCD Scientists Advance Understanding of Molecules in Deafness Genes, Head & Neck Cancers

NIH Researchers Characterize Elusive Myosin 15, Protein Linked to a Form of Hereditary Hearing Loss

NIH researchers report that they have purified a key part of myosin 15, a molecular motor protein that helps build healthy hearing structures in the inner ear. Mutations in the myosin 15 gene (MYO15A) have been linked to a form of hereditary deafness in humans. Using a novel approach to express the protein, researchers have revealed the first detailed insight into the molecule’s structure and function, laying the foundation for new treatments for some forms of hearing loss. The new approach to expressing myosin 15 may also help the study of other types of myosin motors, such as skeletal and cardiac muscle myosins, which could accelerate development of targeted drug therapies for heart disease and other health conditions. The study was published online August 11 in the journal Proceedings of the National Academy of Sciences. Read more »

Researchers Find Molecular Similarities Among Head and Neck, Lung, and Bladder Cancers

Researchers at the National Institute on Deafness and Other Communication Disorders (NIDCD), one of the National Institutes of Health (NIH), working as part of a team of scientists with The Cancer Genome Atlas Network, have identified a characteristic molecular pattern shared by head and neck, lung, and some bladder cancers. The molecular profile offers information that could help physicians diagnose and develop new treatment strategies for these diseases. The results of the study appeared online August 7 in the journal Cell. Read more »

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