Cisplatin may cause more permanent hearing loss in people with Cockayne syndrome
May 19, 2016
Chemotherapy drug cisplatin is used to treat breast, prostate, neuroblastoma, melanoma and many other cancers
- May 18, 2016
- University of Southern California
- The chemotherapy drug cisplatin can kill cancer, but it can also cause permanent hearing loss. The drug can kill the sensory cells of the inner ear, a phenomenon that is likely more severe in individuals with Cockayne syndrome, a rare form of dwarfism. The disorder results from mutations in one of two genes involved in repairing DNA damage. Cells can sustain DNA damage from environmental stresses ranging from the sun’s ultraviolet radiation to toxic chemicals such as chemotherapy drugs.
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- Other Source: Key mutations may worsen hearing loss from the chemotherapy drug cisplatin